Many teams raise their level of play under the bright lights, but the Jets don't appear to be one of them. Anyone looking to make Week 1 NFL picks for Jets vs. 49ers on Monday Night Football would be enlightened to know that New York is 0-5 straight-up and against the spread over its last five road primetime games. However, there is just as much evidence to pick the Jets with Week 1 NFL predictions since San Francisco has failed to cover in its last seven home games according to the latest NFL betting trends. Something has to give in 49ers vs. Jets, which will conclude the Week 1 NFL schedule. San Francisco is a 5.5-point favorite, with an Over/Under of 44.5 in the NFL odds.
Whose winless streak will finally come to an end in the NFL spreads? All of the Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on A-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on A-rated NFL picks since Week 7 of the 2022 NFL season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 1 NFL oddsandNFL bettinglines on thespread,money line, andover-under, and locked in picks for every NFL matchup. Head here to see every pick.
Top Week 1 NFL predictions
We can tell you one of the model's strongest Week 1 NFL picks is that the Chargers (-3.5) cover the spread at home versus the Raiders. Las Vegas went 4-0 against the spread in Aidan O'Connell's last four games as a starter, but O'Connell is now holding a clipboard with Gardner Minshew starting. The former Colt didn't have the same spread success as his backup, as Minshew enters the 2024 NFL season with three straight ATS defeats as a starter. Additionally, the Week 1 history between these teams doesn't favor Las Vegas since the Chargers have won four straight season-openers versus the Raiders.
The Jim Harbaugh effect can't be overstated for L.A. In his first season with the 49ers, he took a team that ranked 15th in turnover differential to first in his debut season. The Chargers had a similar differential ranking of 16th last year, but their offense is already ahead of where San Francisco's was when Harbaugh took over. SportsLine's model projects Los Angeles to score nearly a touchdown more than the 20.4 points per game they averaged last year as L.A. (-3.5) covers well over 60% of the time.See which other teams to pick here.
Another one of its Week 1 NFL predictions: the Bills (-6) cover at home versus the Cardinals. Being at home is important, as the Bills have hosted the Cardinals five times in franchise history, and they've covered in all five of those games. Overall, Buffalo is 7-1 against the spread over the last eight meetings with Arizona.
Both teams have dual-threat QBs, but the defenses they will oppose aren't on par. The model gives Josh Allen the edge in that regard as he faces a unit that ranked 31st in scoring defense last year, while Kyler Murray has to face the fourth-ranked defense. Allen is projected to have one more passing TD than Murray, while also having 20 more rushing yards than the Cards QB. With Buffalo's defense forecasted to have twice as many sacks as Arizona's, the Bills are expected to win by two scores and cover nearly 70% of the time.See which other teams to pick here.
How to make Week 1 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 1 NFL schedule and just revealed four teams that win outright over 70% of the time.You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence, and which four favorites should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 1 NFL betting odds, lines, spreads
Get Week 1 NFL picks at SportsLine
Thursday, Sept. 5
Ravens at Chiefs (-3, 46.5)
Friday, Sept. 6
Packers vs. Eagles (-2.5, 48.5) -- in Brazil
Sunday, Sept. 8
Steelers at Falcons (-3, 42.5)
Cardinals at Bills (-6, 48)
Titans at Bears (-4.5, 45.5)
Patriots at Bengals (-8.5, 40.5)
Texans at Colts (+2.5, 48.5)
Jaguars at Dolphins (-3, 49.5)
Panthers at Saints (-4, 41.5)
Vikings at Giants (+1, 41.5)
Raiders at Chargers (-3.5, 40.5)
Broncos at Seahawks (-5.5, 42)
Cowboys at Browns (-2.5, 42)
Commanders at Buccaneers (-3.5, 43.5)
Rams at Lions (-3.5, 51)
Monday, Sept. 9
Jets at 49ers (-3.5, 43.5)
